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bnt 151  (BioNTech)

 
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    BioNTech bnt 151
    Schematic diagram of <t>IVT</t> <t>mRNA</t> in cancer vaccine. ( A ) Conventional mRNA. ( B ) Self-amplifying mRNA includes four genes encoding four non-structural proteins (nsP1–4) required for the formation of a functional replicase. Subsequently, the replicase uses the mRNA as a template to self-amplify. The gene of interest can be expressed through the control of a subgenomic promoter. ( C ) Trans -amplifying RNA consists of two kinds of <t>mRNAs,</t> one retaining a replicase encoding gene, the other expressing the gene of interest. Figure created with BioRender (biorender.com). Abbreviations: IVT, in vitro transcription; UTR, untranslated region; nsP, non-structural protein
    Bnt 151, supplied by BioNTech, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/bnt 151/product/BioNTech
    Average 90 stars, based on 1 article reviews
    bnt 151 - by Bioz Stars, 2026-06
    90/100 stars

    Images

    1) Product Images from "mRNA vaccines in the context of cancer treatment: from concept to application"

    Article Title: mRNA vaccines in the context of cancer treatment: from concept to application

    Journal: Journal of Translational Medicine

    doi: 10.1186/s12967-024-06033-6

    Schematic diagram of IVT mRNA in cancer vaccine. ( A ) Conventional mRNA. ( B ) Self-amplifying mRNA includes four genes encoding four non-structural proteins (nsP1–4) required for the formation of a functional replicase. Subsequently, the replicase uses the mRNA as a template to self-amplify. The gene of interest can be expressed through the control of a subgenomic promoter. ( C ) Trans -amplifying RNA consists of two kinds of mRNAs, one retaining a replicase encoding gene, the other expressing the gene of interest. Figure created with BioRender (biorender.com). Abbreviations: IVT, in vitro transcription; UTR, untranslated region; nsP, non-structural protein
    Figure Legend Snippet: Schematic diagram of IVT mRNA in cancer vaccine. ( A ) Conventional mRNA. ( B ) Self-amplifying mRNA includes four genes encoding four non-structural proteins (nsP1–4) required for the formation of a functional replicase. Subsequently, the replicase uses the mRNA as a template to self-amplify. The gene of interest can be expressed through the control of a subgenomic promoter. ( C ) Trans -amplifying RNA consists of two kinds of mRNAs, one retaining a replicase encoding gene, the other expressing the gene of interest. Figure created with BioRender (biorender.com). Abbreviations: IVT, in vitro transcription; UTR, untranslated region; nsP, non-structural protein

    Techniques Used: Functional Assay, Control, Expressing, In Vitro



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    Schematic diagram of <t>IVT</t> <t>mRNA</t> in cancer vaccine. ( A ) Conventional mRNA. ( B ) Self-amplifying mRNA includes four genes encoding four non-structural proteins (nsP1–4) required for the formation of a functional replicase. Subsequently, the replicase uses the mRNA as a template to self-amplify. The gene of interest can be expressed through the control of a subgenomic promoter. ( C ) Trans -amplifying RNA consists of two kinds of <t>mRNAs,</t> one retaining a replicase encoding gene, the other expressing the gene of interest. Figure created with BioRender (biorender.com). Abbreviations: IVT, in vitro transcription; UTR, untranslated region; nsP, non-structural protein
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    Schematic diagram of <t>IVT</t> <t>mRNA</t> in cancer vaccine. ( A ) Conventional mRNA. ( B ) Self-amplifying mRNA includes four genes encoding four non-structural proteins (nsP1–4) required for the formation of a functional replicase. Subsequently, the replicase uses the mRNA as a template to self-amplify. The gene of interest can be expressed through the control of a subgenomic promoter. ( C ) Trans -amplifying RNA consists of two kinds of <t>mRNAs,</t> one retaining a replicase encoding gene, the other expressing the gene of interest. Figure created with BioRender (biorender.com). Abbreviations: IVT, in vitro transcription; UTR, untranslated region; nsP, non-structural protein
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    Schematic diagram of <t>IVT</t> <t>mRNA</t> in cancer vaccine. ( A ) Conventional mRNA. ( B ) Self-amplifying mRNA includes four genes encoding four non-structural proteins (nsP1–4) required for the formation of a functional replicase. Subsequently, the replicase uses the mRNA as a template to self-amplify. The gene of interest can be expressed through the control of a subgenomic promoter. ( C ) Trans -amplifying RNA consists of two kinds of <t>mRNAs,</t> one retaining a replicase encoding gene, the other expressing the gene of interest. Figure created with BioRender (biorender.com). Abbreviations: IVT, in vitro transcription; UTR, untranslated region; nsP, non-structural protein
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    Schematic diagram of IVT mRNA in cancer vaccine. ( A ) Conventional mRNA. ( B ) Self-amplifying mRNA includes four genes encoding four non-structural proteins (nsP1–4) required for the formation of a functional replicase. Subsequently, the replicase uses the mRNA as a template to self-amplify. The gene of interest can be expressed through the control of a subgenomic promoter. ( C ) Trans -amplifying RNA consists of two kinds of mRNAs, one retaining a replicase encoding gene, the other expressing the gene of interest. Figure created with BioRender (biorender.com). Abbreviations: IVT, in vitro transcription; UTR, untranslated region; nsP, non-structural protein

    Journal: Journal of Translational Medicine

    Article Title: mRNA vaccines in the context of cancer treatment: from concept to application

    doi: 10.1186/s12967-024-06033-6

    Figure Lengend Snippet: Schematic diagram of IVT mRNA in cancer vaccine. ( A ) Conventional mRNA. ( B ) Self-amplifying mRNA includes four genes encoding four non-structural proteins (nsP1–4) required for the formation of a functional replicase. Subsequently, the replicase uses the mRNA as a template to self-amplify. The gene of interest can be expressed through the control of a subgenomic promoter. ( C ) Trans -amplifying RNA consists of two kinds of mRNAs, one retaining a replicase encoding gene, the other expressing the gene of interest. Figure created with BioRender (biorender.com). Abbreviations: IVT, in vitro transcription; UTR, untranslated region; nsP, non-structural protein

    Article Snippet: Similarly, BioNTech, Moderna as well as CureVac also explored several other platforms for cytokine-encoding mRNAs (BioNTech: BNT 151–153 and BNT 131; Moderna: mRNA-2416, mRNA 2752 and MEDI1191; CureVac: CV8102, CV9201 and CV9202) that induce amplified T cell responses and overcome tumor-mediated immunosuppressive effects [ ].

    Techniques: Functional Assay, Control, Expressing, In Vitro